2003 – Biobran https://biobran.org Sun, 23 Aug 2026 14:58:19 +0000 en-US hourly 1 https://wordpress.org/?v=7.1 https://biobran.org/wp-content/uploads/2026/08/cropped-FaviBB-1-32x32.webp 2003 – Biobran https://biobran.org 32 32 The orally administration of the Hydrolysis Rice Bran prevents a common cold syndrome for the elderly people based on immunomodulatory function https://biobran.org/the-orally-administration-of-the-hydrolysis-rice-bran-prevents-a-common-cold-syndrome-for-the-elderly-people-based-on-immunomodulatory-function/ Thu, 14 Aug 2003 16:40:46 +0000 https://biobran.org/?p=553 The preventive effect of RIBEX against the common cold syndrome was examined on elderly people. RIBEX, containing arabinoxylan derivatives Hydrolysis Rice Bran (HRB), was prepared from the water soluble dietary fiber fraction from rice bran through partial processing by carbohydrate complex of Lentinus Edodes mycelia (shiitake). Using the non-chemical and non-biological treated water soluble fraction of Rice Bran (RB) as control, the examination was conducted by the cross-over double blind manner through the administration term of 6 weeks for each material. Fifty elderly people who stayed in a care institution under Japan`s Long-term Care Insurance participated in this study. The results of thirty-six participants who showed comparative data in both terms were analyzed stastistically. The most popular reason for withdrawal from the study was “leaving from the institution by a care contact”. There was no withdrawal due to the side effects of test foods. We observed symptoms such as “cough”, “fatigue”, “fever”, “sore throat”, “sputum”, “nasal signs”, and “sore breast”, and calculated them, based on the juggements of the medical staff. Although thirteen participants (36.1%) experienced at least one symptom in the both terms, the total scores were significantly high value (p<0.05) in the term of R.B. The average duration in which the participants experienced symptoms was 2.6 days in the term of RB whereas 1.2 days in that of HRB, which was not statistically significant. While there are many reports that HRB increases NK cell activity, no significant data was observed in this study because the participants had enough NK cell acitivites from the start.

HRB shortened the duration of the symptoms, reduced the worse and the necessity of symptomatic therapy, and was useful for the reduction of physical burden of acute respiratory tract infection.

]]> Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin https://biobran.org/modified-rice-bran-beneficial-for-weight-loss-of-mice-as-a-major-and-acute-adverse-effect-of-cisplatin/ https://biobran.org/modified-rice-bran-beneficial-for-weight-loss-of-mice-as-a-major-and-acute-adverse-effect-of-cisplatin/#respond Thu, 14 Aug 2003 16:36:00 +0000 https://biobran.org/?p=551 Alkylating agents and antimetabolites remain prominent in a wide variety of cancer chemotherapy protocols on the basis of more selective effects on the faster than normal mitotic cycles of malignant cells. Among new platinum‐containing anticancer molecules, the lead compound cisplatin (Cis‐platinum (II) diammine dichloride) has been known to possess beneficial anticancer properties in terms of specific interaction of cisplatin and DNA strands. Cisplatin (Rosenberg et al. 1969) has been encouraged for treatment of head and neck, bladder, and cervical cancers (Loehrer & Einhorn 1984), as well as breast cancer (Smith & Talbot 1992). Although the prevalent incidence of lung, gastric, breast, colorectal and prostate cancers place them in top ranks of the most common cancers in the civilized countries, many of these advanced cancers are unresponsive to chemotherapy. Platinum‐based drugs would be a potent choice in these situations, but they frequently cause substantial side effects, such as nausea, vomiting, nephropathy and hypomagnesaemia due to damage of renal tubules (Lajer & Daugaard 1999). Furthermore, in addition to hearing loss and peripheral neuropathy, myelosuppression is one of the most devastating suppressive side‐effects (Prestayko et al. 1979) leading to immunocompromized states. Therefore, any reduction of the side effects of cisplatin would be valuable. Thus, we explored the effect of modified rice bran on protection of weight loss of mice under tolerable maximal doses of cisplatin. Others have briefly commented on the antistress and antifatigue effects of fermented rice bran (Kim et al. 2001) or some beneficial effect of modified rice bran on some adverse actions of anticancer drugs in rats (Jacoby et al. 2000).

]]> https://biobran.org/modified-rice-bran-beneficial-for-weight-loss-of-mice-as-a-major-and-acute-adverse-effect-of-cisplatin/feed/ 0 Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-inducted apoptosis https://biobran.org/modified-arabinoxylan-rice-bran-mgn-3-biobran-sensitizes-human-t-cell-leukemia-cells-to-death-receptor-cd95-inducted-apoptosis/ Thu, 14 Aug 2003 16:34:00 +0000 https://biobran.org/?p=548 MGN-3, an arabinoxylan extracted from rice bran that is treated enzymatically with an extract from Shiitaki mushrooms, is an effective biological response modifier that increases NK cell activity, and potentiates the activity of conventional chemotherapeutic agents. In this study, we investigated the effect of MGN-3 on death receptor-induced apoptosis in the human leukemic HUT 78 cell line. HUT 78 cells were pre-treated with MGN-3, and then were incubated with the agonistic antibody against death receptor (Fas, CD95). Apoptosis was determined by the propidium iodide technique using FACScan. Activation of caspase 3, caspase 8, and caspase 9 was determined by flow cytometry. Mitochondrial membrane potential was measured with DIOC(6) dye using FACScan. Expression of CD95 and Bcl-2 were measured by flow cytometry. In a dose-dependent manner, MGN-3 enhanced anti-CD95 antibody-induced apoptosis. Increased cell death was correlated with increased depolarization of mitochondrial membrane potential and increased activation of caspase 3, caspase 8, and caspase 9. MGN-3 treatment had no effect on the level of expression of CD95, but it caused down regulation of Bcl-2 expression. These results suggest that MGN-3 increases the susceptibility of cancer cells to undergo apoptosis mediated by death ligands, which may be relevant for anti-cancer activities.

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