2004 – Biobran https://biobran.org Sun, 23 Aug 2026 14:57:06 +0000 en-US hourly 1 https://wordpress.org/?v=7.1 https://biobran.org/wp-content/uploads/2026/08/cropped-FaviBB-1-32x32.webp 2004 – Biobran https://biobran.org 32 32 Home Products Research Distributors Contact A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer https://biobran.org/home-products-research-distributors-contact-a-case-where-an-immunomodulatory-food-was-effective-in-conservative-therapy-for-progressive-terminal-pancreatic-cancer/ https://biobran.org/home-products-research-distributors-contact-a-case-where-an-immunomodulatory-food-was-effective-in-conservative-therapy-for-progressive-terminal-pancreatic-cancer/#respond Sat, 14 Aug 2004 17:51:00 +0000 https://biobran.org/?p=580 A patient with terminal pancreatic cancer accompanied by distant metastasis who was unfit for radical surgical treatment was subjected to treatment with the rice bran arabinoxylan derivative, which is reported to have biological defense action, and PI water, which can enhance blood circulation and transportation of nutrients and drugs (Vehicle action), in addition to low toxic chemotherapeutic agents in order to maintain biological functions and QOL. As a result, satisfactory therapeutic effects were obtained, such as improvements in biological functions and spontaneous cure power.

]]> https://biobran.org/home-products-research-distributors-contact-a-case-where-an-immunomodulatory-food-was-effective-in-conservative-therapy-for-progressive-terminal-pancreatic-cancer/feed/ 0 Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran) https://biobran.org/augmentation-of-macrophage-phagocytosis-by-modified-arabinoxylan-rice-bran-mgn-3-biobran/ https://biobran.org/augmentation-of-macrophage-phagocytosis-by-modified-arabinoxylan-rice-bran-mgn-3-biobran/#respond Sat, 14 Aug 2004 17:49:00 +0000 https://biobran.org/?p=578 MGN-3/Biobran, modified arabinoxylan rice bran, has been shown to be a potent biological response modifier (BRM) as manifested by stimulation of different arms of the immune system such as NK, T and B cells; however, its effect on macrophages has not yet been studied. The effects of MGN-3 on macrophage function was examined in vitro using 3 models: human macrophage cell line U937, murine macrophage cell line RAW264.7, and murine peritoneal macrophages (P-M phi). Treatment with MGN-3 resulted in an increase in the percentages of attachment and phagocytosis of yeast by macrophages. The effect depends on the type of macrophage and the dose of MGN-3 applied. Macrophages also demonstrated enhancement in their spreading ability, post treatment with MGN-3. Results also showed that MGN-3, in a dose dependent manner (1, 10,100 microg/ml), significantly induced high levels of production of cytokines: TNF-alpha; and IL-6. In addition, MGN-3 significantly increased nitric oxide (NO) production. This data demonstrates that MGN-3 is a potent inducer of phagocytic function by macrophage, and suggests that MGN-3 is a useful agent for fighting microbial infection.

]]> https://biobran.org/augmentation-of-macrophage-phagocytosis-by-modified-arabinoxylan-rice-bran-mgn-3-biobran/feed/ 0 Effect of Long-term Administration of Immunomodulatory Food on Cancer Patients Cmpleting Conventional Treatments https://biobran.org/effect-of-long-term-administration-of-immunomodulatory-food-on-cancer-patients-cmpleting-conventional-treatments/ https://biobran.org/effect-of-long-term-administration-of-immunomodulatory-food-on-cancer-patients-cmpleting-conventional-treatments/#respond Sat, 14 Aug 2004 17:48:00 +0000 https://biobran.org/?p=576 A study was conducted to investigate the effects of long—term administration of the immunomodulatory food modified arabinoxylan from rice bran (BioBran/MGN-3), on 16 cancer patients, mainly in stage IV with various conventional lesions, who had just undergone conventional cancer treatments, such as surgery, chemotherapy and radiotherapy. The main clinical observations were the safety and effect of BioBran on the nutritional state of the patiens, who were exhausted due to treatment. During the adminstration period, no decreases in body weight and leukocyte count or significant changes in leukogram were observed. Rather, the leukocyte count increased. In addition, most patients showed an increase in NK cell activity and a remarkable decrease in tumor markers.

]]> https://biobran.org/effect-of-long-term-administration-of-immunomodulatory-food-on-cancer-patients-cmpleting-conventional-treatments/feed/ 0 Home Products Research Distributors Contact Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). https://biobran.org/home-products-research-distributors-contact-enhancement-of-natural-killer-cell-activity-of-aged-mice-by-modified-arabinoxylan-rice-bran-mgn-3-biobran/ Sat, 14 Aug 2004 17:47:00 +0000 https://biobran.org/?p=573 The present study is aimed to examine the possibility of enhancement of natural killer (NK) cell activity in aged C57BL/6 and C3H mice using MGN-3, a modified arabinoxylan from rice bran. Intraperitoneal injection of MGN-3 (10 mg kg(-1) per day) caused a remarkable increase in the peritoneal NK activity as early as 2 days (35.2 lytic units), and the level remained elevated through day 14. The control aged mice had a level of 5.8 lytic units. Enhancement in NK activity was associated with an increase in both the binding capacity of NK cells to tumour targets and in the granular content as measured by BLT-esterase activity. Treatment did not alter the percentage of peritoneal NK cells. Data showed that peritoneal macrophages inhibit NK activity. In conclusion, MGN-3 enhances murine NK activity of aged mice and may be useful for enhancing NK function in aged humans.

]]> Home Products Research Distributors Contact Experience with Administration of BioBran in Patients with Chronic Rheumatism https://biobran.org/home-products-research-distributors-contact-experience-with-administration-of-biobran-in-patients-with-chronic-rheumatism/ https://biobran.org/home-products-research-distributors-contact-experience-with-administration-of-biobran-in-patients-with-chronic-rheumatism/#respond Sat, 14 Aug 2004 17:31:00 +0000 https://biobran.org/?p=567 The functional food, rice bran arabynoxylan derivative (BioBran), was administered for a long period to patients with chronic rheumatism given mainly symptomatic treatments with steroids, to evaluate its supplementary effect with representative treatments for rheumatism, such as steroids, analgesics, and thermotherapy. Steroids are essential for treatment of rheumatism, but it is desirable to minimize the dose, because they may cause adverse reactions. In recent years, there have been many reports on the functions of food ingredients, including superoxide scavenging and biophylaxis improving actions. This study evaluated the efficacy of BioBran, a functional food material. BioBran has been reported to have the effects of activating natural killer cells (NK cells) and inhibiting inflammation. The author confirmed and reported that it relieved cold symptoms in the elderly. The present study, where 8 patients with chronic rheumatism were given BioBran for 6 to 12 months, demonstrated the improvements of symptoms and QOL, suggesting its effectiveness.

]]> https://biobran.org/home-products-research-distributors-contact-experience-with-administration-of-biobran-in-patients-with-chronic-rheumatism/feed/ 0 One Case of a Patient with Umbilical Metastasis of Recurrent Cancer (Sister Mary Joseph’s Nodule, SMJN) Who has Survived for a Long Time under Immunomodulatory Supplement Therapy https://biobran.org/one-case-of-a-patient-with-umbilical-metastasis-of-recurrent-cancer-sister-mary-josephs-nodule-smjn-who-has-survived-for-a-long-time-under-immunomodulatory-supplement-therapy/ https://biobran.org/one-case-of-a-patient-with-umbilical-metastasis-of-recurrent-cancer-sister-mary-josephs-nodule-smjn-who-has-survived-for-a-long-time-under-immunomodulatory-supplement-therapy/#respond Sat, 14 Aug 2004 17:14:00 +0000 https://biobran.org/?p=565 A 64-year-old female patient with umbilical metastasis of recurrent colorectal cancer (SMJN) was subjected to complementary medicine using the rice bran arabinoxylan derivative, a food component of BRM activity in addition to chemotherapy in order to maintain the QOL and prolong life. Although the umbilical metastasis is tending to grow, the patient is in a good nutritional condition and has survived for more than two years from diagnosis. SMJN is a distant metastasis, and even if it is the first occurrence, radical treatment may not be possible in most cases. This case suggests tha the maintenance of the QOL and physiological function may lead to a prolongation of life even in patients with terminal cancer with extremely poor prognosis like this. And this case presents the benefit of supplementary therapy using functional foods.

]]> https://biobran.org/one-case-of-a-patient-with-umbilical-metastasis-of-recurrent-cancer-sister-mary-josephs-nodule-smjn-who-has-survived-for-a-long-time-under-immunomodulatory-supplement-therapy/feed/ 0 Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action https://biobran.org/oral-administration-of-hydrolyzed-rice-bran-prevents-the-common-cold-syndrome-in-the-elderly-based-on-its-immunomodulatory-action/ https://biobran.org/oral-administration-of-hydrolyzed-rice-bran-prevents-the-common-cold-syndrome-in-the-elderly-based-on-its-immunomodulatory-action/#respond Sat, 14 Aug 2004 17:12:00 +0000 https://biobran.org/?p=563 The preventive effect of Hydrolyzed Rice Bran against the common cold syndrome was examined in elderly people. Arabinoxylan derivatives of Hydrolyzed Rice Bran (HRB) were prepared from water-soluble rice bran through partial processing using a carbohydrate complex. Using the water-soluble Rice Bran (RB) as a control, a cross over double-blind study was conducted on both substances over a 6-week administration period. Fifty elderly people aged from 70 to 95 years participated in the study and the comparative data from 36 participants were analyzed. There were no withdrawals from in the study due to the side effects of the experimental foods. Symptoms were observed and scored. The total symptom score for the RB treatment group was three times higher than that for the HRB treatment group. The average duration of symptoms was 2.6 days for RB whereas it was only 1.2 days for HRB. Furthermore, some immunomodulatory action was observed in laboratory tests. HRB was shown to be useful in reducing the physical stress associated with acute respiratory tract infection.

]]> https://biobran.org/oral-administration-of-hydrolyzed-rice-bran-prevents-the-common-cold-syndrome-in-the-elderly-based-on-its-immunomodulatory-action/feed/ 0 The Clinical Significance of BioBran in the Immunotherapy for Cancer https://biobran.org/the-clinical-significance-of-biobran-in-the-immunotherapy-for-cancer/ https://biobran.org/the-clinical-significance-of-biobran-in-the-immunotherapy-for-cancer/#respond Sat, 14 Aug 2004 16:42:00 +0000 https://biobran.org/?p=558 The clinical treatments for cancer were surgery, radiotherapy, and chemotherapy with anticancer drugs. For surgery, even if the procedure used is highly sophisticated, cancer cells may be transported to other organs via the vascular or lymph system. For radiotherapy, although it destroys cancer tissues it may also damage the surrounding functioning tissues. Anticancer drugs may destroy cancer cells as well as normally functioning cells of other organs. 

Consequently, these drawbacks of the three types of treatments must be recognized when addressing cancer patients. This is where immunotherapy counts. The author has been working with immunotherapy for 25 years, and this time chose combination therapy with BioBran (rice bran arabinoxylan derivative), and BRP (Bio-Reproducing Protein) intravenously.

Case 1. K. M. 67-year-old, M. Liver cancer with intestinal metastasis

Case 2. M. O. 65-year-old, M. Liver cancer

Case 3. F. M. 71-year-old, F. Liver cancer

Case 4. H. H. 76-year-old, F. Lung cancer

Case 5. T. O. 58-year-old, M. Colorectal cancer with liver metastasis

Above five cases, blood samples were taken once a month to measure tumor markers and immunopotency, and the results were compared with the change in clinical conditions. As a result, improvements were noted in all the cases.

]]> https://biobran.org/the-clinical-significance-of-biobran-in-the-immunotherapy-for-cancer/feed/ 0 The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer https://biobran.org/the-life-prolongation-and-qol-improvement-effect-of-rice-bran-arabinoxylan-derivative-mgn-3-biobran-for-progressive-cancer/ https://biobran.org/the-life-prolongation-and-qol-improvement-effect-of-rice-bran-arabinoxylan-derivative-mgn-3-biobran-for-progressive-cancer/#respond Sat, 14 Aug 2004 16:41:00 +0000 https://biobran.org/?p=556 The present study was designed to deremine whether or not the administration of MGN-3 coud have its apothanasia effect and improve the QOL for 205 progressive and partially metastasized cancer patients in late III-IV stages after surgery. MGN-3 is a rice bran arabinoxylan derivative and known to have immunomodulation activity. The participants in this clinical study are hospitalized patients in our clinic treated with complementary alternative medicines (we call it “Non-Conventional Therapy”) and anticancer medicines with lesser side effects. The 205 patients hospitalized for 6 months were grouped into two groups, viz, 109 patients (control group) treated with our standard complementary alternative medicines, and 96 patients who were further given MGN-3 (MGN-3 group) for one year and a half. 

All the patients were measured for natural killer activity as an indication for the variation of immunoparameters. Simultaneously, the QOL of the patients was also checked. The NK cell activities of the patients after surgery were low on average; however, by the administration of MGN-3, NK activity was observed to increase and the apothanasia ratio aslo increased; the higher the patient NK activity is, the higher the apothanasia ratio was observed to rise. The above findings indicate that NK activity can be used as a pathological index of progressive cancers. QOL improvement was also observed with the adminstration of MGN-3

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