https://biobran.org Sun, 23 Aug 2026 14:45:04 +0000 en-US hourly 1 https://wordpress.org/?v=7.1 https://biobran.org/wp-content/uploads/2026/08/cropped-FaviBB-1-32x32.webp https://biobran.org 32 32 https://biobran.org/metastatic-hemangiopericytoma-of-the-skin-treated-with-wide-local-excision-and-mgn-3/ Mon, 14 Aug 2006 18:00:00 +0000 https://biobran.org/?p=591 Abstract: This case report describes an uncommon tumor treated with an unproven medication found by the patient during an Internet search. MGN-3 is an arabinoxylane derived from rice bran that has been enzymatically modified by an extract of the mushroom Hypbomycetes mycelicz. ln vivo murine studies have reported increased natural killer cell activity with MGN-3 supplementation. An in vitro investigation revealed increased tumor necrosis factor or and interferon-y production by peripheral blood lymphocytes treated with MGN-3. In addition, MGN-3 was found to enhance anti-CD95 antibody-induced apoptosis in a human leukemic cell line. This biologic response modifier has been studied in a limited number of patients With human immunodeficiency virus (HIV) disease or cancer, with improvement in natural killer cell function and disease activity over time. Further studies are needed, however, to ascertain the therapeutic benefits of this relatively novel compound.

]]> https://biobran.org/apoptosis-of-breast-cancer-mcf-7-cells-in-vitro-is-induced-specifically-by-yeast-and-not-by-fungal-myceli/ Mon, 14 Aug 2006 17:57:00 +0000 https://biobran.org/?p=588 lt was recently demonstrated that breast cancer cell lines undergo apoptosis following phagocytosis of S. cerevisiae. The present study was undertaken to determine whether other strains of fungi also induce apoptosis in cancer cells. Eight strains of yeast: C. albicans, C. krusei, C. glabrata, C. kefyr, C. neoformans, Y lipolytica, S. cerevisiae and R. rubra, were evaluated at different developmental stages (small yeast cells, large yeast cells and pseudohyphae). In addition, conidia from I four strains of fungal mycelia: Aspergillus, Aspergillus sp., T rubrum and T tonsurans were evaluated. Breast cancer MCF-7 cells in monolayer were cultured with fungi at a ratio of 1:10, respectively, after which phagocytosis and fungi-induced apoptosis of MCF-7 cells were examined. The MCF-7 cells were found to phagocytize all strains of heat-/cilled yeast, regardless of their evelopmental stage. Phagocytosis followed a graduated series: C. krusei > C. glabrata > R. rubra > S. cerevisiae > C. kefyr > C. neoformans > C. albicans > Y. lipolytica. Yeast-induced apoptosis also followed a graded pattern: S. cerevisiae > C. kefyr > C. krusei > C. neofonmans > R. rubra > C. albicans > C. glabrata > Y. lipolytica, as examined by flow cytometry. In contrast, MCF-7 did not phagocytize or undergo apoptosis post-culture with conidia. This data may have clinical implications for the treatment of breast cancer.

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