https://biobran.org Sun, 23 Aug 2026 14:35:11 +0000 en-US hourly 1 https://wordpress.org/?v=7.1 https://biobran.org/wp-content/uploads/2026/08/cropped-FaviBB-1-32x32.webp https://biobran.org 32 32 https://biobran.org/impact-of-ingestion-of-rice-bran-and-shitake-mushroom-extract-on-lymphocyte-function-and-cytokine-production-in-healthy-rats/ https://biobran.org/impact-of-ingestion-of-rice-bran-and-shitake-mushroom-extract-on-lymphocyte-function-and-cytokine-production-in-healthy-rats/#respond Sun, 16 Aug 2009 19:51:00 +0000 https://biobran.org/?p=765 ABSTRACT. This article provides a controlled evaluation of the ability of dietary supplementation with a commercially available rice bran extract modified with shitake mushroom extract (MGN-3) to support the immune function by assessing the ability of immunocytes to proliferate and produce cytokines in response to a mitogenic challenge. Twenty-four male Lewis rats were fed a control diet (Maypo sweetened oatmeal) or Maypo containing the recommended daily dose of MGN-3 for 2 weeks. This treatment modestly enhanced mitogen enhanced proliferation of splenocytes and interferon-gamma (IFN-g) production, and significantly increased proliferation of splenocytes to the superantigen toxic shock syndrome toxin-1 (TSST-1) as well as natural killer (NK) cell activity and production of interleukin-2 (IL-2) by stimulated lymphocytes. These data support the contention that ingestion of MGN-3 can support immune cell function. These data add to a growing body of data showing that ingestion of MGN-3 improves the ability of immune cells to proliferate the lyse tumor cells, suggesting that it may have utility as a dietary aid to support the immune system.

]]> https://biobran.org/impact-of-ingestion-of-rice-bran-and-shitake-mushroom-extract-on-lymphocyte-function-and-cytokine-production-in-healthy-rats/feed/ 0 https://biobran.org/biobran-augmented-maturation-of-human-monocyte-derived-dendritic-cells/ Fri, 14 Aug 2009 18:14:00 +0000 https://biobran.org/?p=609 BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). lmmature DC (iDC) derived from plastic-adhered, lL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix l (CMMl; TNF-alfa, lL-1[5 and 1L-6) or CMM2 (LPS and IFN-y) to induce their maturation into mature DC (matDCl or matDC2, respectively). Different concentrations of BioBran (10, 100, 400 and 1000 ug/ml) were applied in the presence or absence of relevant CMM to assess the effects of BioBran on DC maturation processes. BioBran induced maturation of iDC, as these cells cultured with IL-4/GM-CSF/BioBran down-regulated CD14 and CD1a antigens on cell surface and significantly increased expression of maturation marker CD83. The increase of surface density of costimulatory molecules CD80 and CD86 on iDC in the presence of BioBran was also observed. In addition, BioBran induced functional maturation of iDC, confirmed by decreased endocytic activity of iDC, Furtheremore, BioBran enhanced maturation potential of cytokine mixes, as both matDC1 and matDC2 exposed to BioBran completely lost CD14 and upregulated CD83, CDS0 and CD86 antigens, in comparison to DC matured with the relevant CMM alone. BioBran also increased CD123 antigen expression on all DC subsets. Interestingly, matDC2 matured in the presence of BioBran (400ug/ml) expressed higher levels of CD123 and lower levels of CD11c cell surface antigens, the phenotype represented by CD11c CD123 plasmacytoid DC population. These data demonstrate that BioBran is a potent enhancer of DC maturation and suggest that BioBran might be a useful agent to create the environment that favours DC maturation.

]]>