Effects of rice bran arabinoxylan compound on quality of life of cancer patients during active treatment: a randomised placebo-controlled pilot trial
The effects of a plant-based immunomodulator, rice bran arabinoxylan compound (RBAC), on thequality of life (QoL) of cancer patients during active treatment are unclear. The RBAC-QoL study wasa randomised, placebo-controlled, double-blind feasibility study to address the role of RBAC in cancerpatients receiving systemic therapies. The primary outcome measure was patient-reported functional,symptom, and global QoL scores. […]
Rice Bran Arabinoxylan Compound and Tryptophan Metabolism on Quality of Life of Cancer Patients: A Secondary Analysis of the RBAC QoL Study
Tryptophan metabolism, with its breakdown along the kynurenine pathway, is linked to the diminishing quality oflife (QoL) of cancer patients. Rice bran arabinoxylan compound (RBAC) is a plant-based immunomodulator shownto improve the global QoL and functioning beyond the placebo during systemic cancer treatment in a randomised controlled trial (RBAC-QoL study). However, whether RBAC improved QoL […]
Synchronizing activity of Biobran/MGN-3 with exosomes: Therapeutic targeting of hypoxia pathway to inhibit angiogenesis and proliferation of breast invasive ductal carcinoma
Hypoxia-inducible factors (HIFs) are crucial for understanding and treating breast cancer, as low oxygen levels within tumors are key factors driving cancer progression, metastasis, and therapy resistance. We studied the possible role of exosomes in combination with Biobran/MGN-3, an arabinoxylan rice bran, in the HIF pathway via its pathogenesis and resistance to VEGF or Ang-2 […]
Basophilic Response in Patients with Persistent Symptoms Attributed to Lyme Borreliosis Treated with Hydrolysed Arabinoxylan Rice Bran
Background and Objectives: MGN-3/Biobran (BRM4, Lentin Plus or Ribraxx) is a natural, rice bran-derived arabinoxylan immunoceutical that modulates the adaptive immune response to viral infections. In response to bacterial infections, basophils act as “first responders” and are also associated with modulation of the adaptive immune response. The maturation of pluripotent CD34+ stem cells into basophils […]
Nanoparticle Enhanced. The Protective Effects of MGN-3 BioBran Against Ehrlich Ascites Carcinoma-Induced Toxicity in the Liver, Kidneys and Spleen of Mice
Background: Nanoparticle-enabled targeted drug delivery has proven effective in cancer treatment due to its ability to cross biological barriers, achieve therapeutic concentrations within tumors, and minimize adverse effects on surrounding healthy tissues. MGN-3/Biobran is a widely recognized natural compound known for its anti-inflammatory, antioxidant, and anti-carcinogenic properties. This study examined the effects of natural product […]
Biobran/MGN-3: A Promising Natural Strategy for Mitigating Kidney Damage and Immune Modulation During Etoposide Therapy
Although chemotherapy is one of the pillars in cancer treatment, its side effects have extremely harmful impacts on many of the body’s organs. This study investigates the potential protective effect of the natural product, Biobran/MGN-3, against kidney damage and immune modulation caused by the chemotherapeutic agent Etoposide in rats. Etoposide impairs kidney function, demonstrated by […]
Rice bran arabinoxylan compound as a natural product for cancer treatment – an evidence-based assessment of the effects and mechanisms
Context: Rice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties. Objective: This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment. Methods: This secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, […]
Biobran/MGN-3, an Arabinoxylan Rice Bran, Exerts Anti-COVID-19 Effects and Boosts Immunity in Human Subjects
Corona Virus Disease 19 (COVID-19) has been a major pandemic impacting a huge population worldwide, and it continues to present serious health threats, necessitating the development of novel protective nutraceuticals. Biobran/MGN-3, an arabinoxylan rice bran, is a potent immunomodulator for both humans and animals that has recently been demonstrated to protect against severe acute respiratory […]
Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study
Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), poses a serious global public health threat for which there is currently no satisfactory treatment. This study examines the efficacy of Biobran/MGN-3 against SARS-CoV-2. Biobran is an arabinoxylan rice bran that has been shown to significantly inhibit the related […]
Enhancing effect of streptozotocin-induced insulin deficit on antitumor innate immune defense in rats
Background: There are conflicting data about the relationship between diabetes mellitus and cancer risk in that growing evidence suggest a possible role of endogenous elevated insulin level which is often found in Non-Insulin-Dependent-Diabetes-Mellitus or an exogenous hyperinsulinemia observed often in Insulin-Dependent-Diabetes-Mellitus. In the last years higher attention focused on the role of immunoregulation both in […]