Biobran MGN-3 Academic Research and Articles
Research papers, academic presentations and articles on Biobran MGN-3 arabinoxylan
2025
PEER REVIEWED
Basophilic Response in Patients with Persistent Symptoms Attributed to Lyme Borreliosis Treated with Hydrolysed Arabinoxylan Rice Bran
Basant K. Puri, Gary S. Lee, Georgia Tuckey, Lisa Wyness, Reine Corley, Lucy Monaghan and Sari J. Arminen
Background and Objectives: MGN-3/Biobran (BRM4, Lentin Plus or Ribraxx) is a natural, rice bran-derived arabinoxylan immunoceutical that modulates the adaptive immune response to viral infections. In response to bacterial infections, basophils act as “first responders” and are also associated with ... Read full research
Read full article2025
Nanoparticle Enhanced. The Protective Effects of MGN-3 BioBran Against Ehrlich Ascites Carcinoma-Induced Toxicity in the Liver, Kidneys and Spleen of Mice
Zeinab A Mostafa, Mai Alaa El-Dein, Mamdooh Ghoneum and Nariman K. Badr El-Din
Background: Nanoparticle-enabled targeted drug delivery has proven effective in cancer treatment due to its ability to cross biological barriers, achieve therapeutic concentrations within tumors, and minimize adverse effects on surrounding healthy tissues. MGN-3/Biobran is a widely recognized natural compound known ... Read full research
Read full article2025
Biobran/MGN-3: A Promising Natural Strategy for Mitigating Kidney Damage and Immune Modulation During Etoposide Therapy
Ali M. Eldib, Haytham M. Abdellatif, Osman Suliman, Faris M. Elmahdi, Ibrahim H. Babikir, Shimaa B. Hemdan, Reem M. Emam, Mohamed S. El-Gerbed, Mamdooh H Ghoneum, Attalla F. El-kott, Sara M. Altom
Although chemotherapy is one of the pillars in cancer treatment, its side effects have extremely harmful impacts on many of the body’s organs. This study investigates the potential protective effect of the natural product, Biobran/MGN-3, against kidney damage and immune ... Read full research
Read full article2024
Rice bran arabinoxylan compound as a natural product for cancer treatment – an evidence-based assessment of the effects and mechanisms
Soo Liang Ooi , Peter S. Micalos, Jeanman Kim and Sok Cheon Pak
Context: Rice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties. Objective: This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment. Methods: This secondary analysis of a scoping ... Read full research
Read full article2024
Biobran/MGN-3, an Arabinoxylan Rice Bran, Exerts Anti-COVID-19 Effects and Boosts Immunity in Human Subjects
Sudhanshu Agrawal, Anshu Agrawal and Mamdooh Ghoneum
Corona Virus Disease 19 (COVID-19) has been a major pandemic impacting a huge population worldwide, and it continues to present serious health threats, necessitating the development of novel protective nutraceuticals. Biobran/MGN-3, an arabinoxylan rice bran, is a potent immunomodulator for ... Read full research
Read full article2023
Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study
Mamdooh Ghoneum, Shaymaa Abdulmalek and Hewida H. Fadel
Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), poses a serious global public health threat for which there is currently no satisfactory treatment. This study examines the efficacy of Biobran/MGN-3 against SARS-CoV-2. ... Read full research
Read full article2022
Enhancing effect of streptozotocin-induced insulin deficit on antitumor innate immune defense in rats
Hajto Tibor, Péczely László, Kuzma Monika, Hormay Edina, Ollmann Tamás, Jaksó Pál, Baranyai Lilla and Karádi Zoltán
Background: There are conflicting data about the relationship between diabetes mellitus and cancer risk in that growing evidence suggest a possible role of endogenous elevated insulin level which is often found in Non-Insulin-Dependent-Diabetes-Mellitus or an exogenous hyperinsulinemia observed often in ... Read full research
Read full article2021
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Dieatary Supplementation with BioBran-MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses s in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial
Ahmed F. Elsaid , Sudhanshu Agrawal , Anshu Agrawal and Mamdooh Ghoneum
Abstract: Influenza-like illness (ILI) remains a major cause of severe mortality and morbidity in the elderly. Aging is associated with a decreased ability to sense pathogens and mount effective innate and adaptive immune responses, thus mandating the development of protective ... Read full research
Read full article2021
Clinical Cancer Strategy (Clinical Review)
Serge Jurasunas
This clinical cancer strategy incorporates advancements in cancer treatment based on a multi-approach to the disease that includes targeting apoptosis, immune cell activation, angiogenesis, restoration of cellular respiration, inhibition of inflammatory mediators, not mentioning some secondary factors such as intoxication, ... Read full research
Read full article2020
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Rice bran arabinoxylan compound and quality of life of cancer patients (RBAC – QoL): Study protocol for a randomized pilot feasibility trial
Soo Liang Ooi, Sok Cheon Pak, Peter S. Micalos , Emily Schupfer, Rob Zielinski, Thomas Jeffries, Garth Harris, Terry Golombick, David McKinnon
Introduction : Rice bran arabinoxylan com pound (RBAC) is a nutraceutical for enhancing a depleted immune system during and after cancer treatment. This pilot feasibility trial aims to evaluate the effects of RBAC on cancer patients’ quality of life during ... Read full research
Read full article2020
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The Immunomodulating Effects of Arabinoxylan Rice Bran (Lentin) on Hematologic Profile, Nutritional Status and Quality of Life among Head and Neck Carcinoma Patients Undergoing Radiation Therapy: A Double Blind Randomized Control Trial
Dorothy Faye S. Tan, MD; Jerickson Abbie S. Flores, MD Jose R. Reyes Memorial Medical Cente
Immunostimulants have been explored to reduce the complications of radiation/chemotherapy. This double blind randomized trial aimed to determine the immunomodulating effects of Lentin among head and neck cancer patients in addressing radiation treatment complications such as anemia, leukopenia, weight loss ... Read full research
Read full article2020
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Arabinoxylan rice bran (MGN-3/Biobran) alleviates radiation-induced intestinal barrier dysfunction of mice in a mitochondrion-dependent manner
Zhenguo Zhao , Wei Chengb, Wei Qu , Kai Wang
MGN-3 is an arabinoxylan from rice bran that has been shown to be an excellent antioxidant and radioprotector. This study examined the protective effects of MGN-3 on radiation-induced intestinal injury. Mice were treated with MGN-3 prior to irradiation, then continued ... Read full research
Read full article2020
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Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats
Nariman K. Badr El-Din, Doaa A. Ali, Reem Othman, Samuel W. French, Mamdooh Ghoneum
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and one of the most lethal. MGN-3/Biobran is a natural product derived from rice bran hemicelluloses and has been reported to possess a potent anticancer effect in ... Read full research
Read full article2019
The anti-cancer activity and potential clinical application of rice bran extracts and fermentation products
Yonghui Yu, Jingjie Zhang, Jing Wang and Baogao Sun
Rice bran is the main by-product of rice processing and contains approximately 64% of the nutrients in rice. Its various nutrient elements include rice bran proteins, oil, oryzanol, vitamins, polysaccharides, etc. The use of fermented technology can increase the content ... Read full research
Read full article2019
Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma
Nariman K. Badr El-Din,*, Said K. Areida , Kvan O. Ahmed and Mamdooh Ghoneum
This study examines the ability of arabinoxylan rice bran (MGN-3/Biobran) to enhance the anti-cancer effects of fractionated X-ray irradiation of Ehrlich solid tumor-bearing mice. Swiss albino mice bearing tumors were exposed to the following: (i) Biobran treatment (40 mg/kg/day, intraperitoneal ... Read full research
Read full article2018
The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease
John E. Lewis , Steven E. Atlas, Oscar L. Higuera, Andrea Fiallo, Ammar Rasul, Ashar Farooqi, Olga Kromo, Laura A. Lantigua, Eduard Tiozzo , Judi M. Woolger, Sharon Goldberg, Armando Mendez , Allan E. Rodriguez, and Janet Konefal
The primary objective of the study was to evaluate the effect of a hydrolyzed polysaccharide, Rice Bran Arabinoxylan Compound (RBAC), on biomarkers in adults with nonalcoholic fatty liver disease (NAFLD). A 90-day randomized double-blind placebo-controlled trial examined the effect of ... Read full research
Read full article2018
New Perspectives to Improve the MHC-I Unrestricted Immune Mechanisms against Malignant Tumors
Tibor Hajto
Since malignant tumors parallel with their progression can lose their sensitivity against the MHC-I restricted T lymphocytes because of their escape in tumor antigen presenting, we need immunomodulators which are able to activate MHC-I unrestricted tumoricidal mechanisms of innate immune ... Read full research
Read full article2018
The Novel Effects of a Hydrolyzed Polysaccharide Dietary Supplement on Immune, Hepatic, and Renal Function in Adults with HIV in a Randomized, Double-Blind Placebo-Control Trial
John E. Lewis, Steven E. Atlas, Muhammad H. Abbas, Ammar Rasul, Ashar Farooqi, Laura A. Lantigua, Frederick Michaud, Sharon Goldberg, Lucas C. Lages, Oscar L. Higuera, Andrea Fiallo, Eduard Tiozzo, Judi M. Woolger, Stephanie Ciraula, Armando Mendez, Allan Rodriguez & Janet Konefal
The primary objective of the study was to evaluate the effects of a hydrolyzed polysaccharide, rice bran arabinoxylan compound (RBAC), on immune, hepatic, and renal function in HIV þ individuals. A six-month randomized double-blind placebo-controlled trial was utilized to conduct ... Read full research
Read full article2017
Urgent Necessity for Standardized and Evidence Based Plant Immunomodulators (Such As Rice Bran Arabinoxylan Concentrate/MGN-3) for the Tumor Research
Tibor Hajto
Biological targeting therapies can inhibit the cascade of cell proliferation and enhance the sensitivity of malignant tumor cells against natural immune effector cells. Clinical observations suggest that their combination with evidence based and standardized plant immunomodulators (such as arabinoxylan concentrate ... Read full research
Read full article2017
Can a standardized plant immunomodulator (rice bran arabinoxylan concentrate/MGN-3) increase the effects of MEK and BRAF inhibitors with clinical benefit? Case report of a patient with carcinoma in biliary duct
Tibor Hajto
Background: Targeting hyperactive mitogen-activated protein kinase (MAPK) signaling cascade has proven to be an effective treatment for a variety of different cancers. Using an important member of this cascade, namely MEK (mitogen activated extracellular signal regulation kinase) inhibitors, the clinical ... Read full research
Read full article2017
Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial
Ahmed F. Elsaid, Magda Shaheen and Mamdooh Ghoneum
Abstract. Aging is associated with a decline in natural killer (NK) and natural killer T (NKT) cell function that may contribute to increased susceptibility to malignancy and infection. A preliminary investigation was conducted examining the hypothesis that arabinoxylan rice bran (Biobran/MGN-3), a denatured hemicellulose ... Read full research
Read full article2017
Evidence-Based Review of BioBran/ MGN-3 Arabinoxylan Compound as a Complementary Therapy for Conventional Cancer Treatment
Soo Liang Ooi, MMath, BHSc (Comp Med) , Debbie McMullen, BHSc (Comp Med), Terry Golombick, PhD, Dipl Nut , and Sok Cheon Pak, PhD
Abstract Introduction: Conventional cancer treatment, including surgery, chemotherapy, and radiotherapy, may not be sufficient to eradicate all malignant cells and prevent recurrence. Intensive treatment often leads to a depressed immune system, drug resistance, and toxicity, hampering the treatment outcomes. BioBran/MGN-3 ... Read full research
Read full article2016
Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial
Hosny Salama, Eman Medhat, Magda Shaheen, Abdel-Rahman N Zekri, Tarneem Darwish and Mamdooh Ghoneum
Current treatments for Hepatitis C virus (HCV) have severe side effects and are very expensive. There is a need to explore effective natural therapies against HCV that are less toxic and more cost-effective. In the current study, 37 chronic HCV ... Read full research
Read full article2016
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Controlled pilot study for cancer patients suffering from chronic fatigue syndrome due to chemotherapy treated with BioBran (MGN-3- Arabinoxylane) and targeted radiofrequency heat therapy
Gabriel Petrovics, Gyula Szigeti, Szilárd Hamvas, Ágnes Máté, József Betlehem, Gabriella Hegyi*
Introduction: Although modern therapies for cancer have improved life expectancy, the management of disease and improvement of quality of life (QoL) of patients, especially managing cancer-related pain and chronic fatigue syndrome are still limited. We demonstrate the efficacy of a ... Read full research
Read full article2016
Modified rice bran hemicellulose inhibits vascular endothelial growth factor-induced angiogenesis in vitro via VEGFR2 and its downstream signaling pathways
Xia ZHU, Aya OKUBO, Naoki IGARI, Kentaro NINOMIYA and Yukari EGASHIRA
Angiogenesis is implicated in diverse pathological conditions such as cancer, rheumatoid arthritis, psoriasis, atherosclerosis, and retinal neovascularization. In the present study, we investigated the effects of modified rice bran hemicellulose (MRBH), a water-soluble hemicellulose preparation from rice bran treated with ... Read full research
Read full article2016
From Bench to Bedside: The Growing use of Arabinoxylan Rice Bran (MGN-3 /Biobran) in Cancer Immunotherapy
Mamdooh Ghoneum, Dept of Otolaryngology, Charles Drew University of Medicine and Science, USA
MGN-3/Biobran is a denatured hemicellulose obtained by reacting rice bran hemicellulose with multiple carbohydrate hydrolyzing enzymes from Shiitake mushrooms. Over the last 24 years, our fundamental research objective has been to study the biotherpeutic activity of MGN-3 as a treatment ... Read full research
Read full article2015
Home Products Research Distributors Contact Can a synergistic activation of pattern recognition receptors by plant immunomodulators enhance the effect of oncologic therapy? Case Report of a patient with uterus and ovary sarcoma
Tibor Hajto, Lilla Baranyai, Angelika Kirsch, Monika Kuzma and Pal Perjési
Background: Growing evidence supports the hypothesis that similar to microbes various plant extracts can also contain Pathogenic Associated Molecular Pattern (PAMP)-like structures which can activate type-1 cellular functions of the innate immune system. Since they are important in tumor defense ... Read full research
Read full article2015
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Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell — mediated cytotoxicity against neuroblastoma in vitro and in vivo
Anton Pérez-Martínez, Jaime Valentín, Lucía Fernández, Enrique Hernández-Jiménez, Eduardo López—Collazo, Petra Zerbes, Ellen Schworer, Fernando Nuňéz, Inmaculada Génesis Martín, Hannah Sallis, Miguel Ángel Díaz, Rupert Handgretinger & Matthias Manuel Pfeiffer
Background aims. Natural killer cell (NK) cytotoxic activity plays a major role in natural immunologic defences against malignancies. NK cells are emerging as a tool for adoptive cancer immunotherapies. Arabinoxylan rice bran (MGN-3/Biobran) has been described as a biological response ... Read full research
Read full article2014
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MGN-3/BIOBRAN Enhances Generation of Cytotoxic CD8+ T Cells Via Upregulation of DEC-205 Expression on Dendritic Cells
M. Ghoneum and S. Agrawal
Arabinoxylan rice bran (MGN-3/Biobran) has been shown to be a potent biological response modifier (BRM) that activates different arms of the immune system, including dendritic cells (DCs), which prime CD4+ helper T-cell responses. The present study explores the ability of ... Read full research
Read full article2014
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Therapeutic Effects of Biobran, Modified Arabinoxylan Rice Bran, in Improving Symptoms of Diarrhea Predominant or Mixed Type Irritable Bowel Syndrome: A Pilot, Randomized Controlled Study
Takeshi Kamiya, Michiko Shikano, Mamoru Tanaka, Keiji Ozeki, Masahide Ebi, Takahito Katano, Shingo Hamano, Hirotaka Nishiwaki, Hironobu Tsukamoto, Tsutomu Mizoshita, Yoshinori Mori, Eiji Kubota, Satoshi Tanida, Hiromi Kataoka, Noriaki Okuda, and Takashi Joh
Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance of the lower digestive tract is one of the mechanisms involved in symptom generation in patients with irritable bowel syndrome (IBS). Biobran, arabinoxylan compound derived from rice bran, ... Read full research
Read full article2014
Modified Arabinoxylan from Rice Bran, MGN-3/Biobran, Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro
Mamdooh Ghoneum, Nariman K. Badr El-Din, Doaa A. Ali and Mai Alaa El-Dein
There is an increased interest in alternative treatments that reduce the toxicity of chemotherapy by lowering the drug concentration, whilst maintaining potency against cancer cells. Previous studies have demonstrated that arabinoxylan from rice bran, MGN-3/Biobran, sensitizes human breast cancer cells ... Read full research
Read full article2013
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Case Reports of Cancer Patients with Hepatic Metastases Treated by Standardized Plant Immunomodulatory Preparations
Tibor Hajto and Angelika Kirsch
Background: Metastatic hepatocellular carcinoma often has a multifocal tumor pattern with markedly depressed hepatic function, Hepatic resection in many cases results in no long-term benefit. After a chemotherapy hepatic tumors rarely disappear completely and the duration of responses is short, ... Read full research
Read full article2013
Biobran MGN-3: Effect of reducing side effects of chemotherapy in breast cancer patients
Masood AI, Sheikh R, Anwer RA
Objective: The aim of study was to assess the effect of Biobran in reducing of chemotherapy induced side effects in terms of tiredness, anorexia, vomiting and hair loss and quality of life in terms of weight loss. Setting: Radiotherapy Department, ... Read full research
Read full article2012
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Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body γ-irradiation in mice via restoration of hematopoietic tissues
Mamdooh Ghoneum, Nariman K. Badr El-Din, Salma M. Abdel Fattah and Lucilene Tolentino
The aim of the current study is to examine the protective effect of MGN-3 on overall maintenance of hematopoietic tissue after ƴ-irradiation. MGN-3 is an arabinoxylan from rice bran that has been shown to be a powerful antioxidant and immune ... Read full research
Read full article2012
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Protective effect of low molecular fraction of MGN-3, a modified arabinoxylan from rice bran, on acute liver injury by inhibition of NF-kB and JNK/MAPK expression
Surina Zheng, Shunsuke Sugita, Shizuka Hirai, Yukari Egashira
D-Galactosamine (GaIN) induces acute hepatitis in experimental animals; this hepatitis has been shown to be suppressed by oral or intraperitoneal administration of modified arabinoxylan from rice bran (MGN—3), and active low molecular fraction isolated from MGN-3 (LMW). We previously reported ... Read full research
Read full article2012
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MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients
Danna Cholujova, Jana Jakubikova, Brarnislav Czako, Michaela Marisova, Luba Hunakova, Jozef Duraj, Martin Mistrik, Jan Sedlak.
Abstract: Dendritic cells (DCs) and natural killer (NK) cells are central components of innate immunity for controlling tumor growth. The therapeutic effects of certain anti-myeloma drugs are partially mediated by targeting the innate immune response. In addition, novel types of ... Read full research
Read full article2012
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An Open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adult
K. H. Ali, A. B. Melillo, S. M. Leonard, D. Asthana, Judi M. Woolger, A. H. Wolfson, H. R. McDaniel, J. E. Lewis
Rice Bran Arabinoxylan Compound (RBAC) is a nutritional supplement produced by enzymatic hydrolysis of hemicellulose B derived from rice bran. Several in vitro studies and clinical reports have shown RBAC to possess promising immunomodulating effects, specifically with respect to natural ... Read full research
Read full article2012
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Chemopreventive Properties of Dietary Rice Bran: Current Status and Future Prospects
Angela J. Henderson, Cadie A. Ollila, Ajay Kumar, Erica C. Borresen, Komal Raina, Rajesh Agarwal and Elizabeth P. Ryan
Emerging evidence suggests that dietary rice bran may exert beneficial effects against several types of cancer, such as breast, lung, liver, and colorectal cancer. The chemopreventive potential has been related to the bioactive phytochemrcals present in the bran portion of ... Read full research
Read full article2012
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Suppressive Effect of Modified Arabinoxylan from Rice Bran (MGN-3) on D-Galactosamine-Induced IL-18 Expression and Hepatitis in Rats
S. Zheng, H. Sanada, H. Dohi, S. Hirai and Y. Egashira
We investigated in this study the effect of modified arabinoxylan from rice bran (MGN-3) and its fractions on D-galactosamine (D-GalN)-induced IL-18 expression and hepatitis in rats. Male Wistar rats were pretreated with MGN-3 or fractions of the MGN-3 hydrolysate, or ... Read full research
Read full article2011
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Activation of Human Monocyte-Derived Dendritic Cells In Vitro by the Biological Response Modifier Arabinoxylan Rice Bran (MGN-3/Biobran)
M. Ghoneum and S. Agrawal
Arabinoxylan rice bran (MGN—3/Biobran) is a potent biological response modifier (BRM) that activates natural killer (NK) cells, T cells and monocytes. Currently, little is known regarding the effects of MGN-3 on dendritic cells (DCs), the cell type that bridges innate ... Read full research
Read full article2011
The clinical effectiveness of BioBran in immunotherapy for patients with hepatitis B
Dr. Tran Thi Minh Phuong
Hepatitis B virus (HBV) infection is a serious global health problem with devastating consequences of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. More efficacious treatments, mass immunization programs, and safe injection techniques are essential for eliminating HBV infection and reducing global ... Read full research
Read full article2011
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Synergistic apoptotic effect of Arabinoxylan rice bran (MGN-3/Biobran) and Curcumin (Turmeric) on human multiple myeloma cell line U266 in vitro
M. Ghoneum, S. Gollapudi
The present study was carried out to investigate the synergistic apoptotic potential of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266 , in vitro. U266 cells were cultured with MGN-3 (50 or 100µg/ml) ... Read full research
Read full article2010
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Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial
Mai Hong Bang, Tran Van Piep, Nguyen Tien Thinh, Le Huu Song, Trinh Tuan Dung, Le Van Truong, Le Van Don, Thai Doan Ky, Deyu Pan, Magda Shaheen and Mamdooh Ghoneum
Background and Aims: This study examined the efficacy of arabinoxylan rice bran (MGN-3) in conjunction with an interventional therapy (IT) for the treatment of hepatocellular carcinoma patients. Patients and Methods: A total of sixty-eight patients with hepatocellular carcinoma (stages I ... Read full research
Read full article2009
Impact of Ingestion of Rice Bran and Shitake Mushroom Extract on Lymphocyte Function and Cytokine Production in Healthy Rats
Scott Giese, BS George Richard Sabell, BS, Mary Coussons-Read, PhD
ABSTRACT. This article provides a controlled evaluation of the ability of dietary supplementation with a commercially available rice bran extract modified with shitake mushroom extract (MGN-3) to support the immune function by assessing the ability of immunocytes to proliferate and ... Read full research
Read full article2009
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Biobran-augmented maturation of human monocyte derived dendritic cells
D.Cholujova, J.Jakubikova, J.Sedlak
BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). lmmature DC (iDC) derived from plastic-adhered, lL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine ... Read full research
Read full article2008
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In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice
N. El-Din, E. Noaman and M. Ghoneum
This study was undertaken to investigate the in vivo anti-tumor activity of MGN-3/Biobran, a modified arabinoxylan rice bran. Swiss albino mice were inoculated intramuscularly in the right thigh with Ehrlich ascites carcinoma (EAC) cells. On Day 8, mice bearing a ... Read full research
Read full article2008
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MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin
S. Gollapudi and M. Ghoneum
MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). Our previous studies demonstrated that MGN-3 sensitizes human leukemia cells to death receptor [CD95]-induced apoptosis [Ghoneum M, Gollapudi S. MGN-3 sen sitizes human T ... Read full research
Read full article2008
Epigenetics and Immunosenescence Reversal: An Evidence-Based Longevity Paradigm
Karriem H. Ali, M.D.
Humankind has long thought of aging as a gradual, time-dependent, deterioration in one‘s well-being and quality of life, with an increased incidence and severity of debilitating chronic diseases. However, current medical opinion argues for a fresh, and more enlightened perspective ... Read full research
Read full article2008
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Modulation of the anticancer immunity by natural agents: inhibition of T regulatory lymphocyte generation by arabinoxylan in patients with locally limited or metastatic solid tumors
P. Lissoni, G. Messina, F. Brivio, L. Fumagalli, L. Vigore, F. Rovelli, L. Maruelli, M. Miceli, P. Marchiori, G. Porro, M. Held, G. di Fede, T Uchiyamada
In the last years, several immunomodulating antitumor agents have demonstrated in the nature, particularly from Aloe plant and rice bran. However, the major problem concerning the natural antitumor agents is to define their immune mechanisms of action in relation to ... Read full research
Read full article2008
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Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Intracellular Killing of Microbes by Human Phagocytic Cells In Vitro
M. Ghoneum, M. Matsuura and S. Gollapudi
Phagocytic cells, comprised of neutrophils and moncytyes/macrophages, play a key role in the innate immune response to infection. Our earlier study demonstrated that arabinoxylan rice bran (MGN-3/Biobran) activates murine peritoneal macrophage and macrophage cell lines. ln this study, we investigated ... Read full research
Read full article2007
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Yeast Therapy For the Treatment of Cancer and its Enhancement by MGN-3/Biobran, an Arabinoxylan Rice Bran
M. Ghoneum, J. Brown and S. Gollapudi
Apoptosis constitutes a strictly programmed device for the removal of aged, damaged and abnormal cells. Research in the last decade has revealed a promising future for apoptosis-based cancer therapies. However, chemotherapeutic agents exhibit an indiscriminative killing that involves both cancer ... Read full research
Read full article2006
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Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3
J. Markus, A. Miller, M. Smith, I. Orengo
Abstract: This case report describes an uncommon tumor treated with an unproven medication found by the patient during an Internet search. MGN-3 is an arabinoxylane derived from rice bran that has been enzymatically modified by an extract of the mushroom ... Read full research
Read full article2006
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Apoptosis of Breast Cancer MCF-7 Cells In Vitro is Induced Specifically by Yeast and Not by Fungal Myceli
M. Ghoneum and S. Gollapudi
lt was recently demonstrated that breast cancer cell lines undergo apoptosis following phagocytosis of S. cerevisiae. The present study was undertaken to determine whether other strains of fungi also induce apoptosis in cancer cells. Eight strains of yeast: C. albicans, ... Read full research
Read full article2005
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Synergistic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. cerevisiae-induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells peer-reviewed
M. Ghoneum and S. Gollapudi
We have recently demonstrated that breast cancer cell (BCC) lines undergo apoptosis following phagocytosis of S. cerevisiae. Arabinoxylan rice bran extract (MGN-3/Biobran) has been shown to enhance this effect. Since previous data were obtained using cells in suspension, the present ... Read full research
Read full article2005
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Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Yeast-induced Apoptosis in Human Breast Cancer Cells In Vitro
M. Ghoneum and S. Gollapudi
We have recently reported that phagocytosis of killed Saccharomyces cerevisiae, baker’s yeast, induced apoptosis in human breast cancer cell lines MCF-Z, ZR- 75-1 and HCC70. In this study we have evaluated the ejfect of treatment with MGN-3, a modified arabinoxylan ... Read full research
Read full article2004
Home Products Research Distributors Contact A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer
Kazutoshi KAKETANI, Hanzomon Gastrointestinal Clinic
A patient with terminal pancreatic cancer accompanied by distant metastasis who was unfit for radical surgical treatment was subjected to treatment with the rice bran arabinoxylan derivative, which is reported to have biological defense action, and PI water, which can ... Read full research
Read full article2004
Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran)
Ghoneum M, Matsuura M.
MGN-3/Biobran, modified arabinoxylan rice bran, has been shown to be a potent biological response modifier (BRM) as manifested by stimulation of different arms of the immune system such as NK, T and B cells; however, its effect on macrophages has ... Read full research
Read full article2004
Effect of Long-term Administration of Immunomodulatory Food on Cancer Patients Cmpleting Conventional Treatments
Hiroshi Tsunekawa
A study was conducted to investigate the effects of long—term administration of the immunomodulatory food modified arabinoxylan from rice bran (BioBran/MGN-3), on 16 cancer patients, mainly in stage IV with various conventional lesions, who had just undergone conventional cancer treatments, such as ... Read full research
Read full article2004
Home Products Research Distributors Contact Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran).
Ghoneum M, Abedi S
The present study is aimed to examine the possibility of enhancement of natural killer (NK) cell activity in aged C57BL/6 and C3H mice using MGN-3, a modified arabinoxylan from rice bran. Intraperitoneal injection of MGN-3 (10 mg kg(-1) per day) ... Read full research
Read full article2004
Home Products Research Distributors Contact Experience with Administration of BioBran in Patients with Chronic Rheumatism
Kenichi Ichihashi
The functional food, rice bran arabynoxylan derivative (BioBran), was administered for a long period to patients with chronic rheumatism given mainly symptomatic treatments with steroids, to evaluate its supplementary effect with representative treatments for rheumatism, such as steroids, analgesics, and ... Read full research
Read full article2004
One Case of a Patient with Umbilical Metastasis of Recurrent Cancer (Sister Mary Joseph’s Nodule, SMJN) Who has Survived for a Long Time under Immunomodulatory Supplement Therapy
Tomonori Kawai
A 64-year-old female patient with umbilical metastasis of recurrent colorectal cancer (SMJN) was subjected to complementary medicine using the rice bran arabinoxylan derivative, a food component of BRM activity in addition to chemotherapy in order to maintain the QOL and ... Read full research
Read full article2004
Oral administration of hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action
Maeda H, Ichihashi K, Fujii T, Omura K, Zhu X, Anazawa M, Tazawa K
The preventive effect of Hydrolyzed Rice Bran against the common cold syndrome was examined in elderly people. Arabinoxylan derivatives of Hydrolyzed Rice Bran (HRB) were prepared from water-soluble rice bran through partial processing using a carbohydrate complex. Using the water-soluble ... Read full research
Read full article2004
The Clinical Significance of BioBran in the Immunotherapy for Cancer
Yasushi Okamura
The clinical treatments for cancer were surgery, radiotherapy, and chemotherapy with anticancer drugs. For surgery, even if the procedure used is highly sophisticated, cancer cells may be transported to other organs via the vascular or lymph system. For radiotherapy, although ... Read full research
Read full article2004
The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer
Kihachiro Takahara and Kamataro Sano
The present study was designed to deremine whether or not the administration of MGN-3 coud have its apothanasia effect and improve the QOL for 205 progressive and partially metastasized cancer patients in late III-IV stages after surgery. MGN-3 is a ... Read full research
Read full article2003
The orally administration of the Hydrolysis Rice Bran prevents a common cold syndrome for the elderly people based on immunomodulatory function
Kenji Tazawa, Kenichi Ichihashi, Takako Fujii, Kazunobu Omura, Mari Anazawa, Hiroaki Maeda
The preventive effect of RIBEX against the common cold syndrome was examined on elderly people. RIBEX, containing arabinoxylan derivatives Hydrolysis Rice Bran (HRB), was prepared from the water soluble dietary fiber fraction from rice bran through partial processing by carbohydrate ... Read full research
Read full article2003
Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin
Yuzo Endo, Hiroshi Kanbayashi
Alkylating agents and antimetabolites remain prominent in a wide variety of cancer chemotherapy protocols on the basis of more selective effects on the faster than normal mitotic cycles of malignant cells. Among new platinum‐containing anticancer molecules, the lead compound cisplatin ... Read full research
Read full article2003
PEER REVIEWED
Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-inducted apoptosis
Ghoneum M, Gollapudi S.
MGN-3, an arabinoxylan extracted from rice bran that is treated enzymatically with an extract from Shiitaki mushrooms, is an effective biological response modifier that increases NK cell activity, and potentiates the activity of conventional chemotherapeutic agents. In this study, we ... Read full research
Read full article2002
MODIFIED RICE BRAN, MGN-3, IMPROVES GLUCOSE TORELANCE IN NIDDM ADULT RATS GIVEN STREPTOZOTOCIN AS NEONATES
Ohara I, Onai K, Maeda H
The effect of modified rice bran (MGN-3) on glucose tolerance as studied in NIDDM adult rats and changes in taste preference were also examined. NIDDM adult rats were made by intraperitoneal injection of 100mg streptozotocin at 1.5 days of age. ... Read full research
Read full article2001
The basic study of arabinoxylan compound (MGN-3) on the activation of vital defence
Nobuyuki Sudo, Konen Tatoe, Naomi Koyama, Hideyuki Kanna, Kenji Hirayama, and Chiharu Kubo
Arabinoxylan (hereafter called MGN-3) is a plant polysaccharide processed food with a biophylactic action, which mainly contains polysaccharides such as hemicellulose and arabinoxylan and glycoprotein. MGN-3 is known to have various biophylactic actions such as in vitro NK cell activity ... Read full research
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The Effect of MGN-3 on Cisplatin and Doxorubicin Induced Toxicity in the Rat
Henry I. Jacoby, Gary Wnorowski, Karl Sakata, Hiroaki Maeda
MGN-3 BioBran is derived from rice bran and is produced by the partial hydrolysis of the water soluble hemicellulose fraction of rice bran by carbohydrases derived from Lentius edodes mycelia. It is a biological response modifier producing an increase in natural ... Read full research
Read full article2000
NK Immunorestoration of Cancer Patients by MGN-3, A Modified Arabinoxylan Rice Bran (Study of 32 Patients Followed for up to 4 Years)
M.Ghoneum and J.Brown
NK cells have been characterized as non-B cells or non-T cells lacking the characteristics of mature macrophages which develop from the bone marrow independently of thymic influence. NK cells play a crucial role in tumor rejection, immune surveillance, resistance to ... Read full research
Read full article2000
Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro
Ghoneum M, Jewett A.
Recently, we presented evidence for the role of MGN-3, an enzymatically modified arabinoxylan extracted from rice bran, in potent activation of human natural killer (NK) cell function in vivo and in vitro. In the current study, we examined the mechanism ... Read full research
Read full article2000
Scavenging Activity of MGN-3 (Arabinoxylane from Rice Bran) with Natural Killer Cell Activity on Free Radicals
Kenji Tazawa, Hirohide Namikawa, Naoko Oida, Kayoko ltoh, Miki Yatsuzuka, Jun Koike, Masahiro Masada and Hiroaki Maeda
MGN-3, which produces a remarkable increase in natural killer cell activity, showed a high scavenging rate on hypoxanthine-xanthine oxidase generated superoxide anion radicals, and on ferrous sulfate-hydrogen peroxide and UV light reaction system generated hydroxyl radicals. The S-group of MGN-3 ... Read full research
Read full article1999
PEER REVIEWED
Effects of modified rice bran on serum lipids and taste preference in streptozotocin-induced diabetic rats
kuo Ohara, D Agr, DMS, Ritsuko Tabuchi, PhD, RD, and Kumiko Onai, M Home Econ, RD
The present study was designed to determine whether or not the administration of modified rice bran could improve streptozotocin (STZ)-induced diabetes. Taste preferences were also compared in diabetic and control rats. Male Sprague-Dawley rats were divided into control and diabetic ... Read full research
Read full article1998
Anti-HIV Activity in Vitro of MGN-3, an Activated Arainoxylane from Rice Bran
Mamdooh Ghoneum
MGN-3, an arabinoxylane from rice bran that has been enzymatically modified with extract from Hyphomycetes mycelia, was tested for anti-HIV activity in vitro. MGN-3 activity against HIV-1 (SF strain) was examined in primary cultures of peripheral blood mononuclear cells. MGN-3 ... Read full research
Read full article1998
Enhancement of human natural killer cell activity by modified arabinoxylan from rice bran (MGN-3)
Mamdooh Ghoneum
Arabinoxylane from rice bran (MGN-3) was examined for its augmentory effect on human NK (NK) cell activity in vivo and in vitro. Twenty-four individuals were given MGN-3 orally at three different concentrations: 15, 30 and 45 mg/kg/day for 2 months. ... Read full research
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