Epigenetics and Immunosenescence Reversal: An Evidence-Based Longevity Paradigm
Humankind has long thought of aging as a gradual, time-dependent, deterioration in one‘s well-being and quality of life, with an increased incidence and severity of debilitating chronic diseases. However, current medical opinion argues for a fresh, and more enlightened perspective on aging. Indeed, until recently, clinical medicine has focused more upon mitigating the effects of […]
Modulation of the anticancer immunity by natural agents: inhibition of T regulatory lymphocyte generation by arabinoxylan in patients with locally limited or metastatic solid tumors
In the last years, several immunomodulating antitumor agents have demonstrated in the nature, particularly from Aloe plant and rice bran. However, the major problem concerning the natural antitumor agents is to define their immune mechanisms of action in relation to the more recent advances in tumor immunobiology. At present, the main cause responsible for the lack of […]
Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Intracellular Killing of Microbes by Human Phagocytic Cells In Vitro
Phagocytic cells, comprised of neutrophils and moncytyes/macrophages, play a key role in the innate immune response to infection. Our earlier study demonstrated that arabinoxylan rice bran (MGN-3/Biobran) activates murine peritoneal macrophage and macrophage cell lines. ln this study, we investigated whether MGN-3 can upregulate the phagocytic activity of human phagocytes in peripheral blood to phagocytize […]
Yeast Therapy For the Treatment of Cancer and its Enhancement by MGN-3/Biobran, an Arabinoxylan Rice Bran
Apoptosis constitutes a strictly programmed device for the removal of aged, damaged and abnormal cells. Research in the last decade has revealed a promising future for apoptosis-based cancer therapies. However, chemotherapeutic agents exhibit an indiscriminative killing that involves both cancer cells and many normal cells. It is therefore of particular interest to find agents that […]
Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3
Abstract: This case report describes an uncommon tumor treated with an unproven medication found by the patient during an Internet search. MGN-3 is an arabinoxylane derived from rice bran that has been enzymatically modified by an extract of the mushroom Hypbomycetes mycelicz. ln vivo murine studies have reported increased natural killer cell activity with MGN-3 […]
Apoptosis of Breast Cancer MCF-7 Cells In Vitro is Induced Specifically by Yeast and Not by Fungal Myceli
lt was recently demonstrated that breast cancer cell lines undergo apoptosis following phagocytosis of S. cerevisiae. The present study was undertaken to determine whether other strains of fungi also induce apoptosis in cancer cells. Eight strains of yeast: C. albicans, C. krusei, C. glabrata, C. kefyr, C. neoformans, Y lipolytica, S. cerevisiae and R. rubra, […]
Synergistic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. cerevisiae-induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells peer-reviewed
We have recently demonstrated that breast cancer cell (BCC) lines undergo apoptosis following phagocytosis of S. cerevisiae. Arabinoxylan rice bran extract (MGN-3/Biobran) has been shown to enhance this effect. Since previous data were obtained using cells in suspension, the present study was undertaken to examine monolayer BCC that more closely model cancer cell growth. Monolayers […]
Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Yeast-induced Apoptosis in Human Breast Cancer Cells In Vitro
We have recently reported that phagocytosis of killed Saccharomyces cerevisiae, baker’s yeast, induced apoptosis in human breast cancer cell lines MCF-Z, ZR- 75-1 and HCC70. In this study we have evaluated the ejfect of treatment with MGN-3, a modified arabinoxylan from rice bran, on phagocytosis and yeast-induced apoptosis in breast cancer cells. Cancer cells were […]
Home Products Research Distributors Contact A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer
A patient with terminal pancreatic cancer accompanied by distant metastasis who was unfit for radical surgical treatment was subjected to treatment with the rice bran arabinoxylan derivative, which is reported to have biological defense action, and PI water, which can enhance blood circulation and transportation of nutrients and drugs (Vehicle action), in addition to low […]
Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran)
MGN-3/Biobran, modified arabinoxylan rice bran, has been shown to be a potent biological response modifier (BRM) as manifested by stimulation of different arms of the immune system such as NK, T and B cells; however, its effect on macrophages has not yet been studied. The effects of MGN-3 on macrophage function was examined in vitro […]