NK Immunorestoration of Cancer Patients by MGN-3, A Modified Arabinoxylan Rice Bran (Study of 32 Patients Followed for up to 4 Years)
NK cells have been characterized as non-B cells or non-T cells lacking the characteristics of mature macrophages which develop from the bone marrow independently of thymic influence. NK cells play a crucial role in tumor rejection, immune surveillance, resistance to infections, and immune regulation. NK cell destruction of cancer cells involves a sequence of events. First, […]
Production of tumor necrosis factor-alpha and interferon-gamma from human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice bran, and its synergy with interleukin-2 in vitro
Recently, we presented evidence for the role of MGN-3, an enzymatically modified arabinoxylan extracted from rice bran, in potent activation of human natural killer (NK) cell function in vivo and in vitro. In the current study, we examined the mechanism by which MGN-3 elevated NK cytotoxic activity. We did this by testing the action of […]
Scavenging Activity of MGN-3 (Arabinoxylane from Rice Bran) with Natural Killer Cell Activity on Free Radicals
MGN-3, which produces a remarkable increase in natural killer cell activity, showed a high scavenging rate on hypoxanthine-xanthine oxidase generated superoxide anion radicals, and on ferrous sulfate-hydrogen peroxide and UV light reaction system generated hydroxyl radicals. The S-group of MGN-3 fractions (L>10,000 molecular, 10.000>M>3.000 molecular and 3.000 molecular>S) showed the highest scavenging rate on superoxide […]
Effects of modified rice bran on serum lipids and taste preference in streptozotocin-induced diabetic rats
The present study was designed to determine whether or not the administration of modified rice bran could improve streptozotocin (STZ)-induced diabetes. Taste preferences were also compared in diabetic and control rats. Male Sprague-Dawley rats were divided into control and diabetic groups. A single STZ injection, 65 mg per kg body mass i.p., induced diabetes. Rats […]
Anti-HIV Activity in Vitro of MGN-3, an Activated Arainoxylane from Rice Bran
MGN-3, an arabinoxylane from rice bran that has been enzymatically modified with extract from Hyphomycetes mycelia, was tested for anti-HIV activity in vitro. MGN-3 activity against HIV-1 (SF strain) was examined in primary cultures of peripheral blood mononuclear cells. MGN-3 inhibited HIV-I replication by: (1) inhibition of HIV-1 p24 antigen production in a dose dependent […]
Enhancement of human natural killer cell activity by modified arabinoxylan from rice bran (MGN-3)
Arabinoxylane from rice bran (MGN-3) was examined for its augmentory effect on human NK (NK) cell activity in vivo and in vitro. Twenty-four individuals were given MGN-3 orally at three different concentrations: 15, 30 and 45 mg/kg/day for 2 months. Peripheral blood lymphocyte-NK cell activity was tested by 51Cr release assay against K562 and Raji […]